• Genome-Scale Architecture of Small Molecule Regulatory Networks and the Fundamental Trade-Off between Regulation and Enzymatic Activity
    Abstract Metabolic flux is in part regulated by endogenous small molecules that modulate the catalytic activity of an enzyme, e.g., allosteric inhibition. In contrast to transcriptional regulation of enzymes, technical limitations have hindered the production of a genome-scale atlas of small mol...
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    Abstract Prediction problems in biomedical sciences are generally quite difficult, partially due to incomplete knowledge of how the phenomenon of interest is influenced by the variables and measurements used for prediction, as well as a lack of consensus regarding the ideal predictor(s) for spec...
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  • Analysis of Protein Phosphorylation and Its Functional Impact on Protein-Protein Interactions via Text Mining of the Scientific Literature.
    Abstract Post-translational modifications (PTMs) are one of the main contributors to the diversity of proteoforms in the proteomic landscape. In particular, protein phosphorylation represents an essential regulatory mechanism that plays a role in many biological processes. Protein kinases, the e...
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  • Commentary on the Integration of Model Sharing and Reproducibility Analysis to Scholarly Publishing Workflow in Computational Biomechanics
    As part of a special issue on model sharing and reproducibility in IEEE Transactions on Biomedical Engineering, two manuscripts on computational biomechanics were submitted: A. Rajagopal et al., IEEE Trans. Biomed. Eng., 2016 and A. Schmitz and D. Piovesan, IEEE Trans. Biomed. Eng., 2016. Models us...
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  • Best Practices for HPC Center
    Worldwide Best Practices in Partnerships between HPC Centers and Industrial Users Sponsored by: The National Center for Supercomputing Applications (NCSA) ...
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  • Perspectives on Research in Artificial Intelligence and Artificial General Intelligence Relevant to DoD
    JASON report of January 2017...
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