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Nuclear Receptor Signaling Atlas (NURSA) Hub Open Competition for NURSA Data Source Projects (NDSP
The mission of the Nuclear Receptor Signaling Atlas (NURSA) is to accrue, develop, and communicate information advancing our understanding of the integral role of nuclear receptor signaling in physiology and metabolic diseases, including diabetes, obesity, and reproductive diseases and disorders. Currently, the central core of NURSA is a Hub that provides the integration and cohesion needed to aggregate, annotate, and present state-of-the-art data in a user friendly fashion. A web portal,, interfaces with the broader scientific community. To achieve its goals, the NURSA Informatics Hub solicits Project applications to support innovative research to the Hub. Successful PIs will leverage their individual and collaborative resources to address the scientific goals of this Request for Applications. Three previous similar announcements resulted in 11 NURSA-funded projects that support high quality cross-cutting research.

Contact Dr. Corinne Silva ( 

Deadline for letter of intent:  November 7, 2016
Deadline for electronic application submission:  November 21, 2016
Earliest possible start date: December 15, 2016
NCBI data types, management, monitoring and outreach activities: Kim Pruitt (NCBI)
View slides from the recent BISTI Consortium meeting on NCBI data management activities
THe NIH Commons Credits Portal is now OPEN
The portal supports the NIH Commons Credits Pilot. During the operation of the Pilot, investigators will submit simple and rapid online credit applications to acquire additional resources for extending computational research on active NIH grants. Capabilities of the portal also include a help desk for providing information on the application process; a knowledge base and services catalog to help select suitable conformant cloud services; and a blog for sharing information and experience among investigators.
12/16/2016portal front page
Slides from BISTI Investigator Seminar: Heterogeneous ensembles for biomedical problems and DREAM challenges
Slides from Dr. Gaurav Pandey's February 2nd BISTI presentation.

NSF Dear Colleagure Lette: RFI on Future Needs for Advanced Cyberinfrastructure to Support Science adn Engineering Research
NSF has launched an effort to refresh the Foundation’s cyberinfrastructure vision and strategy, as the current activity,
Cyberinfrastructure Framework for 21st Century Science and Engineering (CIF21), completes its final year.

NSF invites contributions from the whole science, engineering, education, and CI research community to inform this planning effort.

We seek input on scientific challenges, associated cyberinfrastructure needs, and bold ideas to advance research frontiers over the next decade and beyond. 

Please click on title for additional details.

Deadline for submissions: April 5, 2017,  5:00 PM ET. 
3/16/2017Cyberinfrastructure Framework for 21st Century Science and Engineering (CIF21)
Call for Proposals- SPARC -Stimulating Peripheral Activity to Relieve Conditions Announces New Data and Resource Center Opportunity
The NIH Stimulating Peripheral Activity to Relieve Conditions (SPARC) program seeks to advance understanding of the neural control of organ function, laying a mechanistic foundation for the next generation of therapeutic closed-loop neuromodulation devices. The SPARC team has released a new funding announcement, soliciting applications to develop a Data and Resource Center, a central online hub with three core functions: 1) store and facilitate access to all data generated by SPARC; 2) build interactive visualizations of nerve-organ anatomy and function; and 3) host models that predict the effects of nerve stimuli on organ function. Bioinformatics and data science experts are encouraged to apply. Letters of intent are required and are due by April 7, 2017. Questions should be addressed to
FAQs for ESTEEMED Program
For Frequenty Asked Questions for the ESTEEMED Program, please see attached file.

The FOA is PAR-17-221
Biomedical Citizen Science Hub (CitSciBio)
Built on HUBzero®’s open source infrastructure, CitSciBio is a virtual collaboration space designed to help anyone interested in biomedical citizen science and crowdsourcing discover and share resources, form collaborative groups, and share expertise.
NCI Updates on Frontiers for High Performance Computing in Cancer Research and the NCI-DOE collaborative pilots
BISTI April Meeting Presentation                   
NCI-Frederick National Laboratory for Cancer Research
DARPA-MTO program, Lifelong Learning Machines (L2M)
The program will develop new machine learning systems that continue to learn during operation. This will include addressing both the technical and safety challenges associated with runtime learning as well as looking to natural and biological systems for new ideas for robust and efficient adaptive algorithms. The BAA is now published:

Honoring the Legacy of Lee Rosen (NIH/CSR) and Larry Clarke (NIH/NCI), a special session of the BISTI Consortium
Moving Quantitative Imaging Forward-Symposium in Memory of Laurence Clarke. Dr. Clarke was a visionary in the field of cancer imaging with a particular focus on quantitative imaging methods across a range of imaging modalities to support clinical decision-making and cancer research.

Medical imaging and image-guided interventions community-Symposium in Memory of Lee Rosen, PhD. He was the organizer of Biomedical Imaging Technology (BMIT) study section and was a tireless advocate for our field and mentor to many.
Solicitation for Proposals: Math-BIO Centers pertaining to genomes-to-phenomes and Understanding the Rules of Life
This solicitation stems from community feedback received through various venues and listening sessions. A Working Group of Program Directors from BIO/MCB, BIO/IOS and MPS/Division of Mathematical Sciences (DMS) drafted a set of recommendations for an activity in this area. Subsequently, the Simons Foundation committed half of the funding for three small center awards (the intended outcome of the solicitation) over a 5-year period. Up to $2M/yr for 5 years!
Make Data Count: Building a System to Support Recognition of Data as a First Class Research Output
The Alfred P. Sloan Foundation has made a 2-year, $747K award to the California Digital Library, DataCite and DataONE to support collection of usage and citation metrics for data objects. Building on pilot work, this award will result in the launch of a new service that will collate and expose data level metrics.
Quantitative Imaging Methods and Translational Developments – Honoring the Memory of Dr. Larry Clarke
Special Section in the Journal of Medical Imaging:  Quantitative Imaging Methods and Translational Developments – Honoring the Memory of Dr. Larry Clarke.

NIH Data Commons Pilot Phase (RM-17-026)
In the first stage, awardees will design innovative solutions that meet the needs of one or more of the computational, data and scientific key capabilities of the Data Commons. It is expected that awardees will participate collectively as a consortium and work cooperatively toward achieving NIH’s comprehensive vision for an interoperable, FAIR (Findable, Accessible, Interoperable and Reusable) compliant, multi-cloud NIH Data Commons founded on open source and open standards. The Commons will be designed to comply with the principles of making digital objects FAIR. In the second stage, the solutions developed by the DCPPC will be implemented.
BISTI Consortium Meeting (July 7, 2017)
Dr. Michele Taylor presented on EPS’s Integrated Risk Information Systems (IRIS) for Chemical Evaluations. (presentation included) EPA’s IRIS system includes new workbench tools for interactive review of current literature (SWIFT-REVIEW). Tools includes advanced machine learning capabilities to find related studies and advanced visualization tools to quickly review literature as a compendium. Current assessment indicates a ~23% improvement in work saved over other methods.
NIH awards to test ways to store, access, share, and compute on biomedical data in the cloud
Twelve awards totaling $9 million in Fiscal Year 2017 will launch a National Institutes of Health Data Commons Pilot Phase. A data commons is a shared virtual space where scientists can work with the digital objects of biomedical research, such as data and analytical tools. The NIH Data Commons will be implemented in a four-year pilot phase to explore the feasibility and best practices for making digital objects available through collaborative platforms. For more information please see the full press release at
NCI Request for Information (RFI)
Input on Development of the NCI Imaging Data Commons (NOT-CA-18-060) POC: Stephen Jett (NCI)
Vacancy Announcement
Director, Center for Biomedical Informatics and Information Technology
BISTI Seminar May 2018
Data Use Ontology System (DUOS) and its role in data sharing through Firecloud By Antony Philippakis and Moran Cabili, Broad Institute.