NIH and Government Programs and Initiatives in Biomedical Informatics and Computational Biology (BICB)

Maintained by the BISTI consortium. Send comments, suggestions to Peter Lyster.

This is a list of NIH programs and initiatives with a preponderance of or a significant component of biomedical informatics and computational biology (BICB).  A Program is an ongoing effort with prior and possibly future funding opportunity announcements, while an Initiative specifically refers to an active FOA*.  Some P&I appear twice.
*Active FOAs are identified by (A)

Tips on writing a grant in Biomedical Informatics and Computational Biology.

How to Approach NIH for Support for a Computational Project.

For an update on funding of computational grant applications at NIH read the recent editorial in Biocomputational Review.

View a link to the summary of NIH programs in Systems Biology.

Broad-based BISTI initiatives

  • NEW: BD2K-LINCS DCIC External Data Science Research Project: Request for Collaborative Applications.
  • The Biomedical Information Science and Technology Initiative (BISTI)
  •  BREAKING NEWS: Broad-based BISTI-Big Data (BD2K) FOAs: Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R01) (PA-14-155) (R01);  Extended Development, Hardening and Dissemination of Technologies in Biomedical Computing, Informatics and Big Data Science (R01)
    (PA-14-156);  Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R43/R44) (PA-14-154); Early Stage Development of Technologies in Biomedical Computing, Informatics, and Big Data Science (R41/R42) (PA-14-157). Note that BISTI also keeps a list of R01 contact program staff and SBIR/STTR contact program staff.
  • Collaborations with National Centers for Biomedical Computing (R01) – PAR-12-001 (A). The R21 Exploratory FOA has been discontinued.
  • Retired: NSF-NIH Interagency Initiative: Core Techniques and Technologies for Advancing Big Data Science and Engineering (BIGDATA) (NOT-GM-12-109) .

Broad-based or multi Institute Programs and Initiatives

  • BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain (R01) RFA-EB-15-006
  • Exploratory Technologies to Understand the Control of Organ Function by the Peripheral Nervous System for SPARC (U18) RFA-RM-15-002
  • Predictive Multiscale Models for Biomedical, Biological, Behavioral, Environmental and Clinical Research (U01) PAR-15-085
  • NIH Big Data group BD2K
  • BREAKING NEWS: The final BAA for the cancer genomics cloud pilots was posted to FedBizOps yesterday, and is available here. Proposals are due at 4:00 PM EST, Feb 27, 2104. Additional information can be found at the NCI cloud web page ( or by submitting questions to Please feel free to notify interested parties of this opportunity.
  • BREAKING NEWS: Release of BRAIN Funding Opportunities (A)
  • BREAKING NEWS: Development of an NIH BD2K Data Discovery Index Coordination Consortium (U24) RFA-HL-14-031 (A)
  • BREAKING NEWS: BD2K-LINCS-Perturbation Data Coordination and Integration Center (DCIC) (U54) RFA-HG-14-001 (A)
  • Centers of Excellence for Big Data Computing in the Biomedical Sciences (U54) RFA-HG-13-009
  • Request for Information (RFI): Input on Development of Analysis Methods and Software for Big Data NOT-HG-13-014
  • Research Project Grant (Parent R01) – PA-11-260, NIH Exploratory Developmental Research Grant Program (R21) – PA-10-069, and the Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications – PA-12-089.  The majority of computational applications go to mainline NIH study sections (BDMA, MABS, BCHI, NT, GCAT, MSFD, BMRD, BMIT, MEDI, and MIS) (A)
  • Modeling Social Behavior (R01) – RFA-GM-13-006
  • Interagency Modeling and Analysis Group (IMAG) and IMAG New Funding Opportunities (A)
  • Collaborative Research in Computational Neuroscience (CRCNS): A Joint NSF-NIH initiative: NSF-11-505 (A)
  • Predictive Multiscale Models for Biomedical, Biological, Environmental and Clinical Research (Interagency U01)—PAR-11-203 (A)
  • IMAG Population Modeling Funding Announcements (A)
  • OBSSR Funding Opportunity Announcements in Systems Science (A)
  • Basic Behavioral and Social Sciences Network (OppNet) (A)
  • Social Network Analysis and Health (R01) – PAR-10-145
  • Systems Science and Health in the Behavioral and Social Sciences (R01) PAR-11-314 (R21) PAR-11-315
  • Social Network Analysis and Health, One receipt date per year (R01) PAR-10-145 (R21) PAR-10-146
  • Dissemination and Implementation Research in Health, PAR-10-038 (R01), PAR-10-039 (R03), PAR-10-040 (R21)
  • Mechanisms Underlying the Links between Psychosocial Stress, Aging, the Brain and the Body (R01) -- PA-09-216
  • Climate Change and Health: Assessing and Modeling Population Vulnerability to Climate Change (R21) – PAR-10-235
  • Transforming Biomedicine at the Interface of the Life and Physical Sciences (R01) – PAR-10-141  
  • New Biomedical Frontiers at the Interface of the Life and Physical Sciences (R01) – PAR-10-142
  • Bioengineering Research Partnerships (R01) – PAR-10-234  
  • Bioengineering Research Grants (R01) – PA-10-009
  • Exploratory/Developmental Bioengineering Research Grants (EBRG) (R21) – PA-10-010
  • Notice of Availability of Administrative Supplements for the U.S.-JAPAN Brain Research Cooperative Program – U.S. Component – NOT-NS-10-014
  • Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA) (R01) – RFA-GM-11-003 RETIRED and replaced by
  • NIH Director’s Transformative Research Awards (R01) – RFA-RM-11-006 (A)
  • Spatial Uncertainty: Data, Modeling, and Communication (R01) – PA-11-238, (R21) – PA-11-239, (R03) – PA-11-240
  • Lab to Marketplace: Tools for Brain and Behavioral Research (SBIR[R43/44]) – PA-11-134
  • SHIFT Award: Small Business Helping Investigators to Fuel  the Translation of Scientific Discoveries [SBIR: R43/R44] – PAR-10-122

Institute Programs or Initiatives

Common Fund and Neuroscience Blueprint Programs or Initiatives

Training Opportunities

  • Short Courses on Mathematical, Statistical, and Computational Tools for Studying Biological Systems (R25) – PA-11-351 
  • Mentored Quantitative Research Development Award (K25) – PA-11-196 
  • Ruth L. Kirschstein National Research Service Award (NRSA) Institutional Research Training Grants (T32) – PA-11-184
  • NIH Pathway to Independence (PI) Award (K99/R00) – PA-11-197 
  • Ruth L. Kirschstein National Research Service Awards (NRSA) for Individual Postdoctoral Fellows (F32) – PA-11-113
  • NLM Independent Career Development Award for Biomedical Informatics – (K22)  PAR-10-195

Multi-Agency Programs and Initiatives

Other Agency, Foundation, and International Efforts

If you have any questions about the programs, feel to email: Peter Lyster
Updated 03/24/2014